Research

Gáliková lab

Molecular Physiology and Ecophysiology

We are a young research team working at the Institute of Zoology at the Slovak Academy of Sciences. Our group is primarily interested in energy metabolism and its regulations.

Survival in a fluctuating environment requires that the animal metabolism constantly adapts to the changes in the internal and external conditions. Dysregulations of the adaptive capacity of metabolism lead to serious metabolic disorders, including cachexia, obesity, and metabolic syndrome. Despite the high prevalence of these disorders, their exact molecular underpinnings are not completely clear and are therefore subjects of intense research. Basic metabolic pathways and their regulations are highly evolutionarily conserved, and therefore, metabolism and its disorders have been often studied in invertebrate models. Over the last several decades, the fruit fly Drosophila melanogaster turned to be a very useful system for such studies.

We use Drosophila to investigate the following aspects of energy homeostasis:

Molecular physiology:

Genetics of obesity

Endocrine regulations of energy balance

Neuroendocrine regulation of hunger and thirst

Ecophysiology:

Thermal biology

Metabolic adaptations

Evolution of life history traits

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Our research is funded by

Slovak Academy of Sciences, Support of Projects Seal of Excellence