Molecular Physiology and Ecophysiology
We are a young research team working at the Institute of Zoology at the Slovak Academy of Sciences. Our group is primarily interested in energy metabolism and its regulations.
Survival in a fluctuating environment requires that the animal metabolism constantly adapts to the changes in the internal and external conditions. Dysregulations of the adaptive capacity of metabolism lead to serious metabolic disorders, including cachexia, obesity, and metabolic syndrome. Despite the high prevalence of these disorders, their exact molecular underpinnings are not completely clear and are therefore subjects of intense research. Basic metabolic pathways and their regulations are highly evolutionarily conserved, and therefore, metabolism and its disorders have been often studied in invertebrate models. Over the last several decades, the fruit fly Drosophila melanogaster turned to be a very useful system for such studies.
We use Drosophila to investigate the following aspects of energy homeostasis:
Genetics of obesity
Endocrine regulations of energy balance
Neuroendocrine regulation of hunger and thirst
Evolution of life history traits
Our research is funded by